Beef Brisket Recipe Pour 3 oz of Liquid Smoke over a 5 to 6 lb brisket in baking pan. Sprinkle with garlic powder. Cover and refrigerate over night. When you are ready to bake sprinkle with worchestershire sauce and pepper. Cover tightly and bake 6 hours 275'. Pan not the meat. Meat should be in the juices. Uncover the meat and drain off most of the juice.